ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cancer Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1562854
This article is part of the Research TopicObesity and Metabolism in Endocrine-Related CancersView all 5 articles
The Impact of Diabetes and Social, biologic and behavioral Determinants of Health on Liver Cancer Risk
Provisionally accepted
- American University of Beirut, Beirut, Lebanon
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Background: Liver cancer has seen a concerning rise in incidence, currently ranked as the sixth most prevalent cancer. Diabetes, along with indices of social, biological, and behavioral determinants of health, was linked to the risk of liver cancer.Aim: We aim to determine the effect of diabetes and selected indices of determinants of health on liver cancer. Methods: Our quantitative study is based on a sample of 239,006 US participants adopted from the BRFSS-2022 data. Our results are summarized using frequency distributions and weighted percentages. Weighted logistic regressions were employed to determine the associations with liver cancer. Results: In this sample population, 73 individuals experienced liver cancer, 12.17% (n=33,776) had diabetes, with a four-fold increase in the odds of liver cancer for individuals with diabetes (OR: 4.27, CI: 1.73-10.57). Employment status, educational level, urban/rural living, smoking status were determinants of health associated with liver cancer as well. Our subgroup analysis focusing exclusively on those diagnosed with liver cancer following their diabetes diagnosis confirmed diabetes as risk factor for liver cancer (OR: 5.44, 95%CI: 1.58-18.70), along with marital status and other determinants of health. Conclusion: Effective diabetes management and addressing key health determinants are crucial for reducing liver cancer risk and improving prevention and treatment outcomes.
Keywords: Behavioral Risk Factor Surveillance System (BRFSS) 2022, Behavioral, Biologic and Social Determinants of Health, diabetes, liver cancer, weighted logistic regression analysis
Received: 18 Jan 2025; Accepted: 05 Jun 2025.
Copyright: © 2025 Shouman, Jaffa and Jaffa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Miran A. Jaffa, American University of Beirut, Beirut, Lebanon
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